Material | Exposure | Reference | Number of conditionsa | Hill equation parametersb | Onset surface area dose (cm2/g lung) for 6% neutrophilsc | ||
---|---|---|---|---|---|---|---|
EC50d | Hill sloped | R2 | |||||
P25 | 2- & 4-week | This work | 25 | 1097 [973–1220] | 2.98 [1.89–4.09] | 0.79 | 430 |
P25 | 13-week | [53] | 5 | 4683 [4109–5256] | 5.86 [0.98–10.7] | 0.91 | 2904 |
P25 | 1-week | 7 | 418 [285–552] | 2.88 [0.89–4.87] | 0.93 | 158 | |
Fine TiO2 | All duration | 25 | 2069 [1990–2148] | 7.34 [5.36–9.32] | 0.99 | 1413 | |
Printex-90 | 4-week | This work | 9 | 5262 [2795–7728] | 2.22 [−0.34–4.78] | 0.55 | 1492 |
Printex-90 | 13-week | 9 | 10,038 [6348–13,728] | 1.37 [0.50–2.24] | 0.88 | 1301 | |
MWNT-7 | 2-, 4- & 13-week | This work | 22 | 61.6 [47.6–75.5] | 1.08 [0.82–1.34] | 0.81 | 4.6 |
+ NM401, NM402, NM403, Nanocyl NC7000 | All duration | + 32 | 90.1 [58.9–121.4] | 0.85 [0.62–1.09] | 0.77 | 3.3 | |
Micronized Baytubes | 13-week | 16 | 6366 [2407–10,326] | 0.72 [0.49–0.95] | 0.87 | 130 |