Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system

Table 4 Serum chemistry values at the end of treatment (EoT) and the recovery (Rec) period (n = 6). Data are expressed as mean value ± SD

Time point	Group	GLDH	Urea	Creatinine	Triglycerides	ALT	Albumin	Total protein
Time point	Group	(U/L)	(mg/dL)	(mg/dL)	(mg/dL)	(U/L)	(mg/dL)	(mg/dL)
EoT	Control (vehicle)	8.00 ± 3.51	39.33 ± 3.14	0.32 ± 0.03	154.83 ± 48.40	37.17 ± 28.25	2.31 ± 0.24	5.27 ± 0.79
	AgNP 0.25 mg/kg bw¹	4.52 ± 2.41^a	33.83 ± 4.92 ^a	0.28 ± 0.01 ^a	93.50 ± 35.49 ^a	18.17 ± 6.31	2.40 ± 0.22	4.60 ± 0.29
	AgNP 1.00 mg/kg bw¹	11.28 ± 3.75	43.83 ± 5.00	0.35 ± 0.11	157.33 ± 36.19	17.83 ± 5.38	2.45 ± 0.29	5.34 ± 0.42
	AgAc 1.55 mg/kg bw²	13.32 ± 11.51	34.83 ± 4.02	0.30 ± 0.04	126.50 ± 100.74	24.33 ± 22.72	2.30 ± 0.16	4.54 ± 0.47
Rec	Control (vehicle)	25.25 ± 12.92	35.83 ± 3.76	0.34 ± 0.02	171.67 ± 105.08	91.83 ± 88.37	2.12 ± 0.14	5.08 ± 0.91
	AgNP 0.25 mg/kg bw¹	21.13 ± 6.99	45.00 ± 4.56^b	0.37 ± 0.04	233.00 ± 49.78	64.33 ± 52.47	2.43 ± 0.18 ^b	5.76 ± 0.83
	AgNP 1.00 mg/kg bw¹	38.62 ± 22.59	47.50 ± 6.38**^/b	0.34 ± 0.06	375.33 ± 124.53**^/b	322.50 ± 267.38	2.34 ± 0.55	5.12 ± 0.35
	AgAc 1.55 mg/kg bw²	17.42 ± 5.71	51.83 ± 6.24***^/b	0.34 ± 0.02	214.33 ± 66.45	99.50 ± 83.54	1.36 ± 0.21 ^b	4.92 ± 0.46

¹ Nominal dose (actual delivered doses were 0.20 and 0.80 mg/kg bw)
²Containing the equivalent dose of 1 mg Ag/kg bw
Statistical significance: ** = p < 0.01; ***p < 0.001 vs Control (Kruskal-Wallis test, followed by Dunn’s multiple comparison test); a = p < 0.05; b = p < 0.01 vs Control (Mann-Whitney U test)

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