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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Diesel exhaust particles alter the profile and function of the gut microbiota upon subchronic oral administration in mice

Fig. 2

Oral DEP exposure alters the composition of the gut microbiota. Αlpha-diversity (A-F) and β-diversity (G, H) of the GM in ApoE−/− (a-c, g) and C57Bl/6 (D-F, H) mice orally exposed to DEP. a-f α-diversities are presented as richness (number of ASVs, a, d), Shannon (b, e) and Simpson indices (c, f), Q-values are for linear trend tests, adjusted for FDR according to the Benjamini-Hochberg method, g, h Principal Coordinates Analysis (PCoA) is based on the weighted UniFrac distance matrix generated from all samples of each group. The dose-dependent effect was assessed by a permutational multivariate analysis of variance (ADONIS) of the weighted UniFrac distance matrix assuming a linear trend effect of the DEP dose on the microbial structure (g, p = 0.02 for ApoE−/−; h, p = 0.001 for C57Bl/6) (n = 8 for ApoE−/−; n = 10 for C57Bl/6).

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Particle and Fibre Toxicology

ISSN: 1743-8977

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