Fig. 2From: LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicalsLCO particles induce MN in lung epithelial cells in vivo. Wistar rats were treated with an oro-pharyngeal aspiration of NaCl (control, CTL), WC-Co, LCO or LTO particles. Inflammation and MN were assessed after 3 d. LDH activity (a) was measured in the BALF, recruited inflammatory cells (b) in the BAL and the frequency of micronuclei (c) in AT-II cells isolated from rat lungs. Image of an AT-II cell containing a micronucleus designated by the red arrow (c). *P < 0.05, **P < 0.01 and ***P < 0.001 relative to CTL mice (t-test or one-way ANOVA followed by a Dunnett’s multiple comparison). Bars represent means ± SEM (N = 2, n = 4 for the first experiment and n = 2 for the second experiment)Back to article page