Table 5 Summary of Measured Endpoints – Beas-2B
| Â | Cytotoxicity | Genotoxicity | Mechanistic | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Agent | ΔΨm | LDH Release | WST1 | Clonogenic Proliferation | yH2AX | (p)-Histone H3 | Nuclear Area | EdU Uptake | Cell Cycle Checkpoint | ROS | CYP1 |
PC | ↓ | ↑ | ↑↓* | ↓ | – | – | – | – | – | – | ↑ |
PC-CNT | ↓ | ↑ | ↑↓* | ↓ | ↑ | ↓ | ↑ | ↓ | – | ↑ | ↑ |
PU | – | – | ↑ | N.D. | – | – | – | – | – | – | ↑ |
PU-CNT | – | – | ↑ | N.D. | – | – | – | – | – | – | ↑ |
B[a]P | ↓ | – | ↑ | ↓ | – | – | ↑ | ↓ | + | ↑ | ↑ |