Female, healthy, adult WKY rats, 8–10 weeks old | dissection time-points for biodistribution analyses | |||||||
---|---|---|---|---|---|---|---|---|
0.75 h/1sta | 0.75 h/2ndb | 4 h | 24 h/1st | 24 h/2ndb | 7d | 28d | ||
[105Ag]AgNP Inhalation, 1½ -hour exposure | # of rats | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
Intratravenous injection of soluble [110mAg]AgNO3 | # of rats | 4 | 4 | |||||
Intratracheal instillation of soluble [110mAg]AgNO3 | # of rats | 4 | 4 | |||||
Oral instillation (gavage) of soluble [110mAg]AgNO3 | # of rats | 4 | 4 |