| | Correlation coefficient | p-value |
|---|
LDH
| 0.183 | 0.195 |
HIF-1α
|
0.311
|
0.025
|
Co content
| 0.245 | 0.080 |
Ni content
| 0.065 | 0.270 |
Bioaccessible Co
| −0.020 | 0.886 |
Bioaccessible Ni
| 0.035 | 0.806 |
Ni + Co content
|
0.480
|
0.0003
|
Bioaccessible Ni + Co
|
0.445
|
0.0004
|
- Bivariate analysis (Pearson correlation) between the inflammatory cell recruitment, selected as marker of lung inflammation and HIF-1α, LDH activity, the particle Ni and/or Co content (μg) or the amount of Ni and/or Co ions (μg) released. Inflammatory cell recruitment was assessed in the BAL, HIF-1α (μg/ml) was measured in lung homogenates, LDH activity (iU/l) in BALF. Co and/or Ni contents were calculated from the administered doses and from the Co and/or Ni % of the particles. Bioaccessible Co and/or Ni represent the amount of bioaccessible ions, calculated from the Co/Ni contained in the administered doses and the % released at pH 4.2 at day 30. Significant relationships are identified in bold
