| Correlation coefficient | p-value |
---|
Co content
| −0.064 | 0.801 |
Ni content
|
0.760
|
0.0002
|
Bioaccessible Co
| −0.079 | 0.755 |
Bioaccessible Ni
|
0.719
|
0.001
|
Ni + Co content
| 0.163 | 0.517 |
Bioaccessible Ni + Co
| 0.176 | 0.484 |
- Mice were treated with 0.5, 1 or 2 mg LIB particles (see Fig. 2). Bivariate analysis (Spearman Rho) between the mortality % at day 18, and the particle Ni and/or Co content (μg) or the amount of Ni and/or Co ions (μg) released. Co and/or Ni contents were calculated from the administered doses and from the Co and/or Ni % of the particles. Bioaccessible Co and/or Ni represent the amount of bioaccessible ions, calculated from the Co/Ni contained in the administered doses and the % released at pH 4.2 at day 14 (mortality was recorded between day 6 and 18). Significant relationships are identified in bold