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Table 1 Aerosol parameters determined over the entire intratracheal inhalation period of 2 h for each exposure

From: Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure

Group of rats

Instrument

1 h

4 h

24 h

7d

28d

CMD (nm), mean ± SD of 40 spectra*

SMPS

23.56 ± 0.68

23.66 ± 1.01

21.61 ± 0.77

20.18 ± 1.25

23.57 ± 0.94

CMD (nm) of averaged + extrapolated spectrum&

SMPS

23.00

23.00

20.00

20.00

20.00

Geom. Std. Dev. (GSD) mean ± SD of 40 spectra*

SMPS

1.48 ± 0.03

1.46 ± 0.02

1.44 ± 0.03

1.45 ± 0.09

1.48 ± 0.03

GSD of averaged + extrapolated spectrum&

SMPS

1.45

1.45

1.45

1.45

1.45

TiO2-NP number concen-tration (106 × #/cm3) &

SMPS

2.23 ± 0.12

2.76 ± 0.18

2.23 ± 0.15

2.6 ± 2.08

2.65 ± 0.21

TiO2-NP number concen-tration (106 × #/cm3)

CPC

2.47 ± 0.86

3.37 ± 0.415

2.51 ± 0.099

2.41 ± 0.168

2.89 ± 0.091

Median diameter (nm) of volume concentration

SMPS

36.03 ± 2.51

34.56 ± 1.42

31.89 ± 1.33

29.73 ± 0.82

35.45 ± 0.79

TiO2-NP volume concen-tration + (10−5 cm3/m3)

SMPS

2.76 ± 0.42

3.29 ± 0.34

2.1 ± 0.29

1.53 ± 0.08

3.32 ± 0.28

Specific 48V aerosol activity on filter (kBq/L)§

filter γ-spec-trometer

1.86

2.37

1.31

1.08

2.03

Mean spec. 48V act. of TiO2-NP (kBq/μg; filter Act / (Vol * dens)

filter, SMPS, γ.spectrom.

12.41

18.49

14.51

15.34

15.72

Mean TiO2-NP aerosol mass conc (filter) (μg/L) #

filter, SMPS, γ-spectrom.

0.15

0.13

0.09

0.07

0.13

derived porous TiO2-NP density (g/cm3)

filter, SMPS, γ-spectrom.

1.83

2.73

2.14

2.27

2.32

  1. Aerosol parameters (mean ± SD; n = 4 of each group)
  2. 1 SMPS data were analyzed by AIM - Instrument Manager Software of TSI Inc. version 7.2.5.0
  3. * Mean of count median diameters (CMD) and geometric standard deviations (GSD) of all 40 SMPS spectra measured in the size range 10 nm - 420 nm
  4. & CMD and GSD of the number size spectrum averaged over all 40 SMPS spectra and mean-square fitted and extrapolated to 1-nm size; see Additional file 1
  5. + Integral particle volume concentration (PVC) of the aerosol distribution (cm3/m3) SMPS derived
  6. § Specific [48V]TiO2-NP aerosol activity determined from an aerosol filter sample continuously collected during each 2-h exposure at 0.3 L/min according to eq. 1 of Additional file 1
  7. # Derived [48V]TiO2-NP aerosol mass concentration (μg/L) dividing the specific 48V aerosol activity (filter, kBq/L) by the specific [48V]TiO2-NP activity concentration 12.4 kBq/μg
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Particle and Fibre Toxicology

ISSN: 1743-8977

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