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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: In utero exposure to ultrafine particles promotes placental stress-induced programming of renin-angiotensin system-related elements in the offspring results in altered blood pressure in adult mice

Fig. 6

In utero exposure to UFP induces cardiovascular programming by DNA hypomethylation of the Agtr1a, Agtr1b and ACE promoter in fetus and adult lung. Percentage of methylated 5 CpG sites in Agtr1a, Agtr1b and ACE promoter in the a, c and e) fetus and b, d and f) lung. n = 4/group; *p < 0.05, **p < 0.01 and *** p < 0.001. Two-way ANOVA. c Protein levels and representative image of Western blot of G) fetus AT1R and H) ACE, and I) lung AT1 and ACE. n = 4/group. Data are expressed as mean ± SEM. * p < 0.05 and ** p < 0.01. One-way ANOVA

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Particle and Fibre Toxicology

ISSN: 1743-8977

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