Lobar evenness of deposition/retention in rat lungs of inhaled silver nanoparticles: an approach for reducing animal use while maximizing endpoints

Table 4 Percent of clearance during 5-day exposure

Lobes	1-day measured	5-day accumulated without clearance	5-day measured	Estimated clearance
Lobes	Deposition (μg)/lobe	(μg)/lobe	(μg)/lobe	%
RCr	1.11	5.55	4.22	23.96
RM	1.53	7.65	5.58	27.06
RCa	2.91	14.55	10.89	25.15
RA	1.45	7.25	4.89	32.55
RL	7.00	35.00	25.58	26.91
LL	3.73	18.65	11.90	36.19
Total lung	10.72	53.60	37.47	30.09

RCr right cranial, RM right median, RCa right caudal, RA right accessory lobe, RL whole right lung, LL left lung; Estimated clearance was calculated by (5-day accumulated without clearance – 5 day measured) / (5-day accumulated without clearance) × 100

ISSN: 1743-8977