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Fig. 9 | Particle and Fibre Toxicology

Fig. 9

From: Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats

Fig. 9

H&E staining and scoring of the cortex, cerebellum, and hippocampus after 3 and 6 months of exposure to traffic-related air pollution in the control, high-efficiency particulate air (HEPA), and particulate matter with an aerodynamic diameter of < 1 μm (PM1) groups. Spongiosis and neuronal shrinkage were observed after 3 and 6 months of exposure to PM1 (× 200). Microabscesses were identified in the cortex after 6 months of PM1 exposure (× 200). 0: No significant lesions. The extent of the lesions was graded from 1 to 5 depending on the severity: 1 = minimal (< 1%); 2 = slight, mild (1%~ 25%); 3 = moderate (26%~ 50%); 4 = moderate/severe (51%~ 75%); 5 = severe/high (76%~ 100%)

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