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Fig. 9 | Particle and Fibre Toxicology

Fig. 9

From: Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca2+-dependent NF-κB and MAPK pathways

Fig. 9

The expression of involved mechanism of inflammation after treatment with ZnO NPs. BV2 cells were treated with ZnO NPs at a dose of 0, 5, 10, 15, 20 or 30 μg/mL for 1, 3, 6 or 12 h. Total proteins were extracted, and the levels of NF-κB, ERK and p38 signaling pathway molecules were analyzed via Western Blot (a). The gray value was semiquantitative as shown in histogram (b). The phosphorylation levels of NF-κB, ERK and p38 were significantly increase after ZnO NPs treatment. Results shown as means ± SD from three independent experiments, compare with control group, *P < 0.05, **P < 0.01. Abbreviations: ZnO: zinc oxide nanoparticles; SD: Standard deviation

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