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Table 3 Summary of in vitro T cell differentiation results

From: Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease

In vitro

Genotype

WT

Ahr−/−

CypTKO

Dose

High

Low

High

Low

High

Low

Th17

SRM1650b PM

↑

–

–

↑

  

SRM2975 PM

–

–

↓

–

  

Treg

SRM1650b PM

↓

↑

    

SRM2975 PM

–

↑

    

Th1

SRM1650b PM

–

–

↓

↑

  

SRM2975 PM

↑

–

↓

–

  

Th17

SRM1650b OF

↑

–

–

–

  

SRM2975 OF

↑

–

–

–

  

Treg

SRM1650b OF

–

–

    

SRM2975 OF

–

↓

    

Treg

SRM1650b PAHs

–

–

    

SRM2975 PAHs

–

↓

    

Th17

SRM1650b PAHs

↑

–

–

–

↑

–

SRM2975 PAHs

–

–

–

–

↑

↑

  1. Both DEP PM enhanced effector T cell differentiation in an AHR-dependent manner and suppressed regulatory T cell differentiation at high doses. Both DEP OF enhanced effector T cell differentiation in an AHR-dependent manner at high doses and SRM2975 OF suppressed regulatory differentiation at low doses. SRM1650b PAH mixtures enhanced Th17 differentiation at high doses in an AHR-dependent manner and SRM2975 PAH mixtures did not. In the absence of CYP metabolizing enzymes, both diesel PAH mixtures enhanced Th17 differentiation at high doses and SRM2975 maintained this effect at low doses. Symbols: ↑ increase, ↓ decrease, − no change