Table 1 Information for genes required for the intestinal development in nematodes
From: Developmental basis for intestinal barrier against the toxicity of graphene oxide
Gene | Encoded protein | Function | Reference |
|---|---|---|---|
act-5 | Actin | Microvilli development | MacQueen et al., [73] |
ifb-2 | Intermediate filament protein | Terminal web development | Carberry et al., [41] |
erm-1 | Ezrin-radixin-moesin protein | Connection between actin cytoskeleton and plasma membrane | Gobel et al., [42] |
eps-8 | Cell signaling adaptor protein | Microvilli length control | Croce et al., [43] |
par-3 | PDZ-domain-containing protein | Apical-basal polarity | Nance and Priess, [44] |
par-6 | PDZ-domain-containing protein | Apical-basal polarity | Nance and Priess, [44] |
pkc-3 | Proetin kinase C | Apical-basal polarity | Wu et al., [45] |
mtm-6 | Myotubularin | Endocytosis | Xue et al., 2003 |
eat-3 | Dynamin | Endocytosis | Labrousse et al., [48] |
gem-4 | Ca2+-dependent phosphatidylserine binding protein | Bush border development | Church and Lambie, [46] |
let-413 | Scribble | Confine apical domain | Legouis et al., [49] |
nfm-1 | Neurofibrularin | Cytoskeletal linker | Culetto and Sattelle, [50] |
unc-64 | Syntaxin | Vesicle secretion | Saifee et al., [52] |
inx-3 | Gap junction channel | Cell adhesion | Altun et al., [51] |
dlg-1 | MAGUK protein | Organization of epithelium to a coherent tube | Segbert et al., [53] |
ajm-1 | Apical junction molecule | Junctional integrity | Koppen et al., [54] |
egl-8 | Phospholipase Cβ | Vesicle secretion | Lackner et al., [55] |
lin-7 | PDZ-domain-containing protein | Organization of large macromolecular complexes | Feng et al., [56] |
hmp-2 | β-catenin | Tissue integrity of intestinal tube | Segbert et al., [53] |
hmp-1 | α-catenin | Tissue integrity of intestinal tube | Segbert et al., [53] |
hmr-1 | Cadherin | Tissue integrity of intestinal tube | Segbert et al., [53] |