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Table 1 MCP230 exposure results in pulmonary Th17 associated cytokine induction

From: Radical containing combustion derived particulate matter enhance pulmonary Th17 inflammation via the aryl hydrocarbon receptor

 

MCP230

Cytokines

12 h

1 d

IL1β

1.446 ± 0.1729

1.691 ± 0.2082a

IL6

45.71 ± 8.457a

10.61 ± 3.177a

IL21

0.7346 ± 0.0256

1.034 ± 0.1367

IL17A

0.6526 ± 0.1302

6.096 ± 1.666a

IL22

0.9377 ± 0.0325

1.504 ± 0.158a

IL17E

0.7034 ± 0.0941

0.9023 ± 0.0322

KC

5.629 ± 1.54 p = 0.053

2.591 ± 0.4729a

MCP-1

6.337 ± 1.325a

6.825 ± 0.2238a

IL33

2.226 ± 0.1384a

2.716 ± 0.1907a

IL31

0.3472 ± 0.07782a

0.4988 ± 0.0489

  1. Levels of Th17 cytokines were determined in the lung homogenates of WT mice exposed to MCP230 at 12 h and 1 day post-exposure. Concentrations (pg/mg of lung protein) of all cytokines were measured using multiplex assay. Data are expressed as means ± SEM of fold change over Vehicle treated controls from 4 to 5 mice. ap < 0.05 compared to vehicle control, unpaired t test