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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Early-life exposure to three size-fractionated ultrafine and fine atmospheric particulates in Beijing exacerbates asthma development in mature mice

Fig. 5

PM exposure in infant mice enhances pulmonary inflammation in adulthood after induction of allergic asthma in vivo. a The exposure protocol to PM and induction of asthma model. PM (F1, F2 and F3: 50 μg per time; F1(s): 15 μg per time) or PBS was administered to juvenile BALB/c mice at 17, 19 and 21 days after birth by oropharyngeal aspiration (OA). An OVA-model of asthma was established at six weeks of age. b The test groups are shown in the table. c Total WBC and the differential counts for Monocyte, Neutrophil, Lymphocyte, Basophil and Eosinophil in BALF were evaluated by differential counting 24 h following the final protocol day. d Serum antibody concentration measured by ELISA. The data are expressed as the mean ± SEM of 5 mice per group. *p < 0.05 vs. Con group; #p < 0.05 vs. OVA group, &p < 0.05 vs. OVA/PM (F1, F2 or F3)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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