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Table 5 Biochemical parameters in lean Zucker rats after repeated exposure to E171 and E153 by oral gavage

From: Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

In vivo Study

Control (n = 9)

E171 (n = 9)

E171 (n = 10)

E153 (n = 10)

E153 (n = 8)

Dose (mg/kg bw/week)

0

50

500

0.64

6.4

Vitamin C (μM) (ascorbate + DHA)

19.6 ± 2.9

20.3 ± 2.6

21.0 ± 4.6

20.5 ± 3.9

18.9 ± 2.9

MDA (μM)

0.20 ± 0.05

0.19 ± 0.08

0.22 ± 0.07

0.20 ± 0.07

0.19 ± 0.05

BH4 (nM)

150.1 ± 20.4

149.2 ± 18.9

154.8 ± 43.7

151.5 ± 20.5

134.5 ± 27.4

BH4/BH2 ratio (nM)

0.20 ± 0.04

0.18 ± 0.04

0.19 ± 0.04

0.17 ± 0.05

0.21 ± 0.05

ADMA (μM)

178.1 ± 31.8

192.3 ± 41.0

179.1 ± 47.0

219.8 ± 118.1

215.1 ± 89.4

L-arginine (μM)

51.0 ± 8.8

61.8 ± 15.8

58.3 ± 16.9

75.5 ± 54.1

75.1 ± 35.5

  1. All biochemical parameters were measured in plasma samples taken at the time of sacrifice. bw: body weight, DHA dehydroascorbic acid, MDA malondialdehyde, BH4 tetrahydrobiopterin, BH2 dihydrobiopterin, ADMA asymmetric dimethylarginine. Data are represented as mean ± SD