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Table 4 Log EC50 and Emax values of concentration-response curves in aorta and left anterior descending coronary artery (LAD)

From: Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

 

Dose (mg/kg bw/week)

Log EC50 (M)

Emax (%)

Aorta

LAD proximal

LAD distal

Aorta

LAD proximal

LAD distal

ACh

Control

0

−5.8 (−6.1 to −5.4)

−7.3 (−7.4 to − 7.2)

−7.5 (− 7.7 to − 7.3)

38.9 (34.6–46.0)

98.2 (94.5–102.0)

93.3 (87.1–100.4)

E171

50

− 6.0 (− 6.7 to − 2.3)

− 7.5 (− 7.6 to − 7.4)

−7.6 (− 7.7 to − 7.4)

43.1 (35.2–131.6)

101.1 (97.6–104.7)

98.0 (92.3–104.5)

500

−6.1 (− 6.6 to − 5.1)

−7.2 (− 7.4 to − 7.1)

−7.6 (− 7.9 to − 7.3)

49.5 (42.4–75.0)

101.4 (96.1–107.4)

112.0* (101.9–124.7)

E153

0.64

−5.9 (− 6.2 to − 5.5)

−7.1 (− 7.2 to − 6.9)

−7.4 (− 7.6 to − 7.3)

34.6 (30.7–41.4)

111.1* (104.3–119.1)

101.4 (95.9–107.6)

6.4

−5.9 (− 6.4 to − 4.3)

−7.5 (− 8.0 to − 7.2)

−7.4 (− 7.6 to − 7.2)

40.2 (33.2–74.1)

98.9 (88.5–116.1)

111.5* (103.5–120.6)

NTG

Control

0

−7.5 (− 7.6 to − 7.4)

− 5.4 (− 6.1 to − 3.0)

−6.7 (− 7.1 to − 6.1)

91.0 (87.2–95.6)

153.1 (115.7–365.2)

111.1 (96.8–144.3)

E171

50

−7.5 (− 7.7 to − 7.2)

− 5.2 (− 6.0 to − 0.1)

−5.9 (− 6.4 to − 4.7)

89.0 (82.2–99.3)

166.2 (118.7–902.1)

143.0 (117.2–226.7)

500

−7.8* (− 8.0 to − 7.7)

− 6.6 (− 7.3 to 2.6)

− 6.2 (− 6.7 to − 4.9)

94.1 (90.5–98.2)

125.8 (98.9–1086.0)

115.3 (94.8–188.8)

E153

0.64

−7.8 (− 8.0 to − 7.6)

− 5.0 (− 5.9 to 0.8)

−6.3 (− 6.9 to − 6.1)

90.2 (85.1–96.8)

176.0 (122.9–1208.0)

126.4 (98.3–480.6)

6.4

−7.7 (− 7.9 to − 7.5)

−6.2 (− 6.6 to − 5.5)

−6.2 (− 7.0 to 17.1)

89.2 (83.8–96.3)

129.5 (111.4–171.2)

142.5 (107.8–26,498.0)

5-HT

Control

0

−5.2 (− 5.3 to − 5.0)

− 6.2 (− 6.4 to − 6.0)

− 6.0 (− 6.2 to − 5.9)

125.8 (117.7–135.4)

158.9 (147.5–171.5)

112.2 (104.4–120.9)

E171

50

−5.1 (− 5.2 to − 5.0)

−6.3 (− 6.4 to − 6.1)

−6.2 (− 6.4 to − 6.0)

128.4 (120.7–137.8)

152.2 (144.1–160.7)

155.4* (141.5–171.3)

500

−5.2 (− 5.4 to − 5.0)

−6.2 (− 6.6 to − 5.8)

−6.1 (− 6.3 to − 5.8)

113.9 (100.4–132.5)

126.9 (111.5–149.5)

113.7 (102.6–126.7)

E153

0.64

−5.0 (− 5.1 to − 4.9)

− 6.3 (− 6.6 to − 5.9)

−6.2 (− 6.4 to − 5.9)

130.8 (122.2–141.1)

172.4 (152.6–201.3)

115.1 (102.6–128.7)

6.4

−5.1 (− 5.3 to − 5.0)

− 6.3 (− 6.6 to − 6.0)

6.1 (− 6.3 to − 5.9)

123.5 (115.2–133.6)

132.8 (119.4–148.9)

112.2 (103.9–121.9)

  1. The concentration-response curves were performed for acetylcholine (ACh), nitroglycerine (NTG) and 5-hydroxytryptamine (5-HT) on the aorta and coronary arteries from rats exposed intragastrically to E171 or E153 once a week for 10 weeks. The data are presented as mean and 95% CI. The number of animals in each group varied; specified in the concentration-response curves (Figs. 6, 7 and 8). An asterisk (*) denotes statistically significant effects when compared to the effect in the control group (P < 0.05)