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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway

Fig. 3

Overexpression of PTPN6 inhibited PDCD4 expression levels both in vitro and in vivo. a expression of PTPN6, PDCD4, BAX and APP in mouse lungs exposed to Al2O3 NPs (n = 10, * P < 0.05, ** P < 0.01, *** P < 0.001). b mRNA and protein expression levels of PTPN6, PDCD4, BAX and APP in A549 and HBE cells (n = 6, * P < 0.05, compared with vehicle-treated control, ** P < 0.01, compared with vehicle-treated control, *** P < 0.001, compared with vehicle-treated control, ## P < 0.01, compared with vehicle/Al2O3 NPs-exposed group, ### P < 0.001, compared with vehicle/Al2O3 NPs-exposed group). c Representative images of PDCD4 expression in mouse lung tissues. LTV: lentivirus; OEX: overexpression

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Particle and Fibre Toxicology

ISSN: 1743-8977

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