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Table 6 Pulmonary clearance rate constants and initial fraction of administered NiO that reached the alveolar region

From: Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats

 

Dose

Clearance rate constants k Lung (1/day)

Half time t 1/2 (day)

Initial fraction reaching the alveolar region r

Translocation rate constants k Lung  → Lym (1/day)

NiO A

0.57 mg/kg-bw

0.0022

310 day

57%

0.00014

1.9 mg/kg-bw

0.000

>690 day

58%

0.00048

5.8 mg/kg-bw

0.0017

410 day

68%

0.00076

NiO B

0.45 mg/kg-bw

0.15

4.5 day

54%

0.000024

1.5 mg/kg-bw

0.16

4.4 day

38%

0.000024

4.0 mg/kg-bw

0.15

4.5 day

36%

0.000039

NiO C

0.47 mg/kg-bw

0.012

59 day

5.0%

0.000031

2.0 mg/kg-bw

0.0041

170 day

20%

0.00017

5.8 mg/kg-bw

0.000

>690 day

42%

0.00050

NiO D

0.50 mg/kg-bw

0.0073

96 day

97%

0.00045

1.6 mg/kg-bw

0.0061

110 day

94%

0.00078

5.0 mg/kg-bw

0.0084

82 day

88%

0.0014

  1. Data estimated from the lung and bronchoalveolar lavage fluid (BALF) burden data, using a one-compartment model