From: Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats
Dose | Clearance rate constants k Lung (1/day) | Half time t 1/2 (day) | Initial fraction reaching the alveolar region r | Translocation rate constants k Lung → Lym (1/day) | |
---|---|---|---|---|---|
NiO A | 0.57 mg/kg-bw | 0.0022 | 310 day | 57% | 0.00014 |
1.9 mg/kg-bw | 0.000 | >690 day | 58% | 0.00048 | |
5.8 mg/kg-bw | 0.0017 | 410 day | 68% | 0.00076 | |
NiO B | 0.45 mg/kg-bw | 0.15 | 4.5 day | 54% | 0.000024 |
1.5 mg/kg-bw | 0.16 | 4.4 day | 38% | 0.000024 | |
4.0 mg/kg-bw | 0.15 | 4.5 day | 36% | 0.000039 | |
NiO C | 0.47 mg/kg-bw | 0.012 | 59 day | 5.0% | 0.000031 |
2.0 mg/kg-bw | 0.0041 | 170 day | 20% | 0.00017 | |
5.8 mg/kg-bw | 0.000 | >690 day | 42% | 0.00050 | |
NiO D | 0.50 mg/kg-bw | 0.0073 | 96 day | 97% | 0.00045 |
1.6 mg/kg-bw | 0.0061 | 110 day | 94% | 0.00078 | |
5.0 mg/kg-bw | 0.0084 | 82 day | 88% | 0.0014 |