Table 5 Percentage of Ni in bronchoalveolar lavage fluid (BALF) per Ni in total lung post-administration
From: Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats
(Ni in BALF) / (Ni in lung and BALF) | ||||
|---|---|---|---|---|
3 days after i.t. | 28 days after i.t. | 91 days after i.t. | ||
NiO A | 0.57 mg/kg-bw | 2.4% ± 1.2% | 0.84% ± 0.11% | 1.2% ± 0.24% |
1.9 mg/kg-bw | 0.59% ± 0.043% | 0.89% ± 0.043% | 0.60% ± 0.041% | |
5.8 mg/kg-bw | 0.79% ± 0.52% | 2.5% ± 0.70% | 0.89% ± 0.48% | |
NiO B | 0.45 mg/kg-bw | 3.0% ± 0.88% | 31% ± 13% | 76% ± 17% |
1.5 mg/kg-bw | 4.0% ± 1.0% | 19% ± 5.0% | 38% ± 2.9% | |
4.0 mg/kg-bw | 2.8% ± 0.82% | 8.9% ± 1.8% | 22% ± 5.8% | |
NiO C | 0.47 mg/kg-bw | 1.7% ± 0.72% | 3.2% ± 1.4% | 5.0% ± 1.5% |
2.0 mg/kg-bw | 3.2% ± 1.4% | 2.5% ± 0.86% | 3.1% ± 1.1% | |
5.8 mg/kg-bw | 5.0% ± 1.5% | 1.3% ± 1.4% | 1.2% ± 0.93% | |
NiO D | 0.50 mg/kg-bw | 2.4% ± 0.29% | 3.7% ± 1.7% | 2.5% ± 0.33% |
1.6 mg/kg-bw | 1.8% ± 0.61% | 5.7% ± 1.1% | 3.2% ± 0.68% | |
5.0 mg/kg-bw | 2.0% ± 0.42% | 2.7% ± 1.3% | 4.8% ± 1.5% | |