From: Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats
(A) Lung | ||||
Percentage of lung NiO burden per administered dose | ||||
3 days after i.t. | 28 days after i.t. | 91 days after i.t. | ||
NiO A | 0·57 mg/kg-bw | 53% ± 11% | 56% ± 8.7% | 46% ± 5.3% |
1·9 mg/kg-bw | 44% ± 21% | 66% ± 8.0% | 62% ± 4.8% | |
5·8 mg/kg-bw | 67% ± 17% | 71% ± 3.0% | 60% ± 14% | |
NiO B | 0·45 mg/kg-bw | 33% ± 1.6% | 0.87% ± 0.051% | 0.28% ± 0.032% |
1·5 mg/kg-bw | 22% ± 1.5% | 0.48% ± 0.10% | 0.12% ± 0.020% | |
4·0 mg/kg-bw | 22% ± 2.1% | 0.50% ± 0.12% | 0.088% ± 0.049% | |
NiO C | 0·47 mg/kg-bw | 4.8% ± 1.3% | 3.4% ± 1.9% | 1.7% ± 0.22% |
2·0 mg/kg-bw | 18% ± 5.5% | 19% ± 9.3% | 13% ± 4.5% | |
5·8 mg/kg-bw | 39% ± 10% | 41% ± 14% | 42% ± 19% | |
NiO D | 0·50 mg/kg-bw | 100% ± 6.3% | 64% ± 12% | 51% ± 3.8% |
1·6 mg/kg-bw | 100% ± 11% | 62% ± 16% | 54% ± 4.0% | |
5·0 mg/kg-bw | 90% ± 16% | 61% ± 16% | 40% ± 7.9% | |
(B) Bronchoalveolar lavage fluid (BALF) | ||||
Percentage of BALF NiO burden per administered dose | ||||
3 days after i.t. | 28 days after i.t. | 91 days after i.t. | ||
NiO A | 0·57 mg/kg-bw | 1.2% ± 0.31% | 0.51% ± 0.13% | 0.59% ± 0.17% |
1·9 mg/kg-bw | 0.28% ± 0.17% | 0.61% ± 0.068% | 0.39% ± 0.034% | |
5·8 mg/kg-bw | 0.51% ± 0.37% | 1.9% ± 0.62% | 0.57% ± 0.42% | |
NiO B | 0·45 mg/kg-bw | 1.1% ± 0.31% | 0.35% ± 0.19% | 0.15% ± 0.058% |
1·5 mg/kg-bw | 0.94% ± 0.22% | 0.11% ± 0.015% | 0.058% ± 0.013% | |
4·0 mg/kg-bw | 0.65% ± 0.19% | 0.050% ± 0.015% | 0.016% ± 0.0049% | |
NiO C | 0·47 mg/kg-bw | 0.078% ± 0.021% | 0.11% ± 0.053% | 0.088% ± 0.031% |
2·0 mg/kg-bw | 0.64% ± 0.81% | 0.45% ± 0.20% | 0.39% ± 0.092% | |
5·8 mg/kg-bw | 0.39% ± 0.098% | 0.50% ± 0.42% | 0.43% ± 0.34% | |
NiO D | 0·50 mg/kg-bw | 2.6% ± 0.39% | 2.5% ± 1.1% | 1.3% ± 0.13% |
1·6 mg/kg-bw | 1.8% ± 0.49% | 3.9% ± 1.6% | 1.8% ± 0.46% | |
5·0 mg/kg-bw | 1.9% ± 0.63% | 1.6% ± 0.74% | 1.9% ± 0.54% | |
(C) Trachea | ||||
Trachea NiO burden per initial body weight [mg/kg bw] | ||||
3 days after i.t. | 28 days after i.t. | 91 days after i.t. | ||
NiO A | 0·57 mg/kg-bw | 0.77% ± 0.25% | 0.38% ± 0.12% | 0.30% ± 0.085% |
1·9 mg/kg-bw | 0.33% ± 0.17% | 0.19% ± 0.050% | 0.20% ± 0.085% | |
5·8 mg/kg-bw | 0.21% ± 0.15% | 0.39% ± 0.16% | 0.16% ± 0.075% | |
NiO B | 0·45 mg/kg-bw | 0.14% ± 0.031% | 0.035% ± 0.047% | 0.023% ± 0.017% |
1·5 mg/kg-bw | 0.10% ± 0.028% | 0.0052% ± 0.0021% | 0.0040% ± 0.00050% | |
4·0 mg/kg-bw | 0.086% ± 0.040% | 0.0020% ± 0.00033% | 0.0015% ± 0.0011% | |
NiO C | 0·47 mg/kg-bw | 0.087% ± 0.030% | 0.027% ± 0.013% | 0.026% ± 0.0097% |
2·0 mg/kg-bw | 0.28% ± 0.14% | 0.19% ± 0.13% | 0.13% ± 0.078% | |
5·8 mg/kg-bw | 0.40% ± 0.19% | 0.29% ± 0.097% | 0.28% ± 0.079% | |
NiO D | 0·50 mg/kg-bw | 0.52% ± 0.084% | 0.38% ± 0.065% | 0.25% ± 0.12% |
1·6 mg/kg-bw | 0.46% ± 0.16% | 0.30% ± 0.12% | 0.15% ± 0.017% | |
5·0 mg/kg-bw | 0.24% ± 0.078% | 0.27% ± 0.19% | 0.21% ± 0.084% | |
(D) Lymph nodes | ||||
Lymph nodes NiO burden per initial body weight [mg/kg bw] | ||||
3 days after i.t. | 28 days after i.t. | 91 days after i.t. | ||
NiO A | 0·57 mg/kg-bw | 0.040% ± 0.019% | 0.75% ± 0.30% | 1.4% ± 0.32% |
1·9 mg/kg-bw | 0.068% ± 0.015% | 1.6% ± 0.14% | 1.7% ± 0.84% | |
5·8 mg/kg-bw | 0.10% ± 0.050% | 3.0% ± 0.26% | 3.6% ± 1.4% | |
NiO B | 0·45 mg/kg-bw | 0.051% ± 0.0053% | 0.031% ± 0.0069% | 0.017% ± 0.0062% |
1·5 mg/kg-bw | 0.025% ± 0.0029% | 0.014% ± 0.0013% | 0.0092% ± 0.0051% | |
4·0 mg/kg-bw | 0.012% ± 0.0018% | 0.012% ± 0.0036% | 0.0040% ± 0.00083% | |
NiO C | 0·47 mg/kg-bw | 0.0088% ± 0.0026% | 0.0062% ± 0.0024% | 0.0057% ± 0.0022% |
2·0 mg/kg-bw | 0.015% ± 0.0061% | 0.065% ± 0.063% | 0.23% ± 0.15% | |
5·8 mg/kg-bw | 0.052% ± 0.023% | 0.67% ± 0.31% | 2.0% ± 1.1% | |
NiO D | 0·50 mg/kg-bw | 0.11% ± 0.0047% | 1.7% ± 0.29% | 2.2% ± 0.63% |
1·6 mg/kg-bw | 0.17% ± 0.020% | 3.0% ± 1.4% | 4.0% ± 0.69% | |
5·0 mg/kg-bw | 0.15% ± 0.018% | 5.2% ± 2.2% | 11% ± 2.4% |