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Table 4 Summary studies of in vivo exposures and focussed investigation of engineered nanomaterial characteristics

From: Mechanistic insight into the impact of nanomaterials on asthma and allergic airway disease

Material Type

Models of Asthma and Allergic Airway Disease

Nanomaterial Characteristics Specifically Investigated for Effects in Models of Asthma and Allergic Airway Disease

Allergen Exposure Models of AAD

Pulmonary Exposure

Primary Size

Solubility

Shape/Structure

Agg size

Charge

Composition

Surface Area

Surface Chemistry/Coating

ALLERGEN INDEP

SENSITISATION

EXACERBATION

CNPs

[41] [40] [60] [37] [38] [59] [58] [62] [238]

[37] [38] [39] [40] [41] [42] [43] [54] [72] [238]

[58] [59, 60] [61, 62] [110]

[127] [277]

[37] [38] [39] [40] [42] [54] [40] [37] [38]

 

[54]

  

[43] [127]

[54]

 

MWCNT

[169] [134] [135] [50] [278] [67] [69] [70] [51] [49]

[49] [50, 51] [54]

[67] [68] [69] [70] [71]

[147]

[49] [54]

 

[49] [54] [134]

   

[54]

 

SWCNT

[136] [52]

[52, 53] [54]

  

[54] [52]

 

[54] [52]

   

[54]

 

CNF

 

[54]

  

[54]

 

[54]

   

[54]

 

AgNP

[132] [111] [116]

 

[111] [112] [116] [274]

 

[132]

   

[132]

  

[132]

AuNP

  

[63] [117]

      

[63]

  

Co3O4NP

   

[126] [127] [279]

     

[126] [127] [279]

  

CuONP

[64] [64]

 

[64]

[279] [280]

 

[280]

   

[279] [280]

  

NiONP

   

[126] [127] [279] [280] [281] [282] [146]

 

[280] [281]

   

[126] [127] [279] [280]

  

TiO2NP

[119] [133] [81] [119]

[43] [55] [120] [81] [273]

[63] [120] [118] [119] [273]

[126] [127] [283]

 

[55]

   

[43] [55] [63] [126] [127]

  

CeO2NP

   

[104]

        

ZnONP

[56] [56]

[55] [56]

 

[280] [194]

 

[55] [56] [280] [194]

   

[55] [280]

 

[55]

Fullerene

 

[106]

          

FeNP

[275] [80]

[80]

[275] [93]

         

GONP

[65]

[65]

[65]

         

Latex NP

[272]

[272]

  

[272] [272]

       

PSPNP

[79]

[44] [79]

  

[44]

       

SiO2NP

[48] [46] [47] [276] [48]

[45] [46, 47] [48] [55]

[66] [276]

 

[45] [55]

[55]

 

[48]

[66]

[55]

[48] [55] [276]

[48] [66] [276]

TOTALS

42

30

27

12

17

5

4

1

2

7

4

5

  1. Abbreviations: Agg agglomerate, GO Graphene Oxide, MWCNT multi-walled carbon nanotubes, SWCNT Single-walled carbon nanotubes, CNF Carbon Nanofibres
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Particle and Fibre Toxicology

ISSN: 1743-8977

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