Table 2 Effect of nanomaterials on experimental in vivo models of established allergic airway disease

Ag

6

0.11

-

Mice (BALBc –f)

OVA (IP)

A

40mg/kg x5d

↓ (Penh)

-

↓

nc

-

nc

↓

↓ (IL-4 IL-5, IL-13, VEGF)

↓ MUC5AC

[112]

Ag

6

-

-

Mice (C57BL/6 –f)

OVA (IP)

A

40mg/kg x5d

↓ (Penh)

-

↓

nc

↓

nc

↓

↓ (IL-4 IL-5, IL-13, NFkB)

-

[111]

Ag

33

-

-

Mice (BALB/c –f)

OVA (IP)

A

3.3mg/m³ x6h/d x7d

-

↑

-

-

-

-

-

-

-

[274]

Ag

33

0.016

-

Mice (BALB/c –f)

OVA (Int N)

A

3.3mg/m³ x6h x7d

nc (Penh)

nc

nc

nc

nc

nc

nc

nc (IL-13) -

-

[116]

Au

40

-

-

Mice (BALB/c –m)

TDI (dermal)

OA

0.8 mg/kg

↑ (Resist)

nc

nc

↑

-

↑

↑

↓ (TNF-α, IL-6) nc (MIP-2, MCP-1)

-

[63]

Au

6.3

-

-

Mice (A/J –m)

OVA (IP)

Int N

60μg/Kg x2

↓ (Resist)

-

↓

-

-

-

-

↓ (IL-4, IL-13, CCL11, CCL24)

↓ PAS

[117]

Au

6.3

-

-

Mice (Swiss Webster –m)

OVA (IP)

Int N

60μg/Kg x2

-

-

↓

↓

-

↓

↓

↓ (IL-5, Il-1β, IL-6, ROS)

-

[117]

TiO₂

22

-

272

Mice (BALB/c –m)

TDI (dermal)

OA

0.8 mg/kg

nc (Resist)

nc

nc

↑

-

↑

↑

nc (TNF-α, IL-6, MIP-2, MCP-1)

-

[63]

CuO

46.67

-

375.8

Mice 0(BALB/c –f)

OVA (IP)

Int N

100μg/kg x3

↑ (Penh)

↑

↑

↑

↑

↑

↑

↑ (ROS, IL-5, IL-6, TNF-α, IL-13, IL-4

↑ MUC5AC

[64]

C

20

442

344-5720

Mice (C57BL/6 –f)

OVA (IP)

PA

10mg/kg

-

-

-

↑

-

nc

↑

-

-

[60]

C

34.8

-

-

Mice (BALB/c)

OVA (A)

A

526μg/m³ x24h

↑ (Penh)

-

↑

-

↑

↑

-

↑(IL-13), ↓(IL-5), nc (IL-4)

↑ PAS

[61]

C

53.2

-

-

Mice (BALB/c –f)

OVA (IP)

A

504μg/m3 (24h)

↑ (Penh)

-

↑

-

↑

nc

↑

↑ (IL-5, IL-13)

-

[110]

C

35.2

-

-

Dog (Beagle)

Ragweed (IP)

A

232.3μg/m³

nc (Resist)

nc

nc

↑

nc

nc

nc

-

-

[58]

C

7

-

-

Mice (BALB/c –f)

OVA (IP)

A

507μg/m³ x24h

-

-

nc

↑*

-

nc

-

↑ (LTB₄, PGE₂), nc (8-isoprostane)

-

[59]

C

7

-

-

Mice (BALB/c)

OVA (IP)

A

507μg/m³ x24h

-

-

-

-

-

-

-

↑ (TNF-α), nc (CC16)

↑ PAS

[62]

α-Fe₂O₃

30

28.98

950-2000

Mice (BALB/c –f)

OVA (IP)

Int T

5mg/kg

-

nc

↓

nc

↓

↓

↓

nc (TNF-α, Il-1β, IL6)

-

[275]

FeO₂

43

41.95

200

Mice (BALB/c –m)

OVA (IP)

Int T

1.1mg/kg x3

-

-

-

-

↑

-

↑

↑ (IFN-γ), nc (IL-4)

-

[93]

GO

D 0.61, L 0.02-2μm

-

-

Mice (BALB/c –f)

OVA (IP)

PA

2.2mg/kg x4

nc (Penh)

nc

nc

↑

↓

nc

-

nc (IL-4, IL-5, IL-13)

-

[65]

SiO₂

14

-

-

Mice (BALB/c –f)

OVA (IP)

Int T

2.7mg/kg

nc (Resist)

-

↑

↑

↑

↓

-

↑ (IL-13, MCP-1, MIP-1, Tarc); nc (IL-4, INF-γ, TNF-α, KC)

↑ MUC5AC PAS

[66]

SiO₂ (PEG)

14

-

-

Mice (BALB/c –f)

OVA (IP)

Int T

2.7mg/kg

↑ (Resist)

-

↑

↑

↑

↓

-

↑ (IL-4, IL-13, MCP-1, MIP-1, Tarc, KC), nc (INF-γ, TNF-α)

↑ MUC5AC PAS

[66]

SiO₂ (PO₄)

14

-

-

Mice (BALB/c –f)

OVA (IP)

Int T

2.7mg/kg

nc (Resist)

-

nc

nc

nc

nc

-

↑ (MIP-1); nc (IL-13, IL-4, INF-γ, TNF-α, MCP-1, Tarc, KC)

nc MUC5AC PAS

[66]

SiO₂ (Amino)

15

-

-

Mice (BALB/c –f)

OVA (IP)

Int T

2.7mg/kg

nc (Resist)

-

nc

nc

nc

↑

-

↑ (IL-13, IL-4); ↓ (Tarc); nc (INF-γ, TNFα, MCP1, KC)

nc MUC5AC PAS

[66]

SiO₂

100

12.7

-

Mice (BALB/c –f)

OVA (IP)

Int N

11 mg/kg x3

nc (Resist)

nc

nc

nc

nc

↑

↑

nc (IL-5, IL-13, IL-1β, INF-γ)

nc PAS

[276]

SiO₂ (Meso)

100

70.6

Mice (BALB/c –f)

OVA (IP)

Int N

11 mg/kg x3

nc (Resist)

nc

nc

nc

nc

↑

nc

nc (IL-5, IL-13, IL-1β, INF-γ)

nc PAS

[276]

SiO₂ (PEG)

100

12.7

-

Mice (BALB/c –f)

OVA (IP)

Int N

11 mg/kg x3

nc (Resist)

nc

nc

nc

nc

nc

nc

nc (IL-5, IL-13, IL-1β, INF-γ)

nc PAS

[276]

TiO₂

5

-

168

Rat (BN –m)

OVA (IP)

A

9.4mg/m³ x6h

-

-

↓

nc

↓

↓

↓

↓ (MCP-1, IL-4, IL-6, INF-γ)

↓ PAS

[118]

TiO₂

21

-

4200

Rat (BN –m)

OVA (In)

A

159 μg, deposited

nc (Resist)

nc

↓

nc

nc

nc

↓

-

-

[119]

TiO₂

21

-

4200

Rat (DA-m)

OVA (In)

A

168 μg, deposited

nc (Resist)

nc

↓

↑

↑

nc

nc

-

-

[119]

TiO₂

21

-

1.5 μm

Mice (BALB/c –f)

OVA (IP)

A

193 μg, deposited

↓ (Resist)

nc

↓

↑

↓

nc

↓

↓ (IL-4, IL-13, IL-5,IL-6, INF-γ)

-

[120]

TiO₂

21

-

1.5 μm

Mice (BALB/c –f)

OVA (IP)

A

32 μg, deposited

↑ (Resist)

-

↑

↑

↑

↑

↑

nc (IL-4, IL-13, IL-5,IL-6, INF-γ)

-

[120]

TiO₂

4-8

130

244

Mice (BALB/c)

OVA (IP)

Int N

5.5 mg/kg x4

nc (Resist)

-

-

-

-

-

-

-

-

[273]

MWCNT

D – 9.5, L– 1.5μm

250-300

-

Rats (BN –f)

TMA (dermal)

A

22mg/m3 x5h x7d

-

nc

nc

nc

↓

nc

nc

-

-

[68]

MWCNT

D - 20–30, L-5-10μm

-

324

Mice (C57BL/6)

HDM (Int N)

O

2 mg/kg

-

nc

nc

↑

nc

↓

↑

nc (IL-1β, IL-13, IL-4, IL-5 CCL20) ↑(CCL2, CXCL1/2)

-

[71]

MWCNT

D 30–50 L 0.3-50μm

109.29

>2 μm

Mice (C57BL/6J)

OVA (IP)

OA

4mg/kg

-

nc

↓*

nc

nc

↓

-

nc (IL-13, IL-5,, IL-17α) ↓(TGF-β1)

nc PAS

[70]

MWCNT

D 30–50 L 0.3-50μm

109.29

-

Mice (C57BL/6 –)

OVA (IP)

A

100mg/m³

-

-

nc

nc

nc

nc

-

nc (IL-13) ↑ (IL-5, TGF-β1)

-

[67]

MWCNT

D 10–30 L 0.3-56μm

-

-

Mice (WT –m)

OVA (IP)

OA

4mg/kg

-

-

nc

nc

nc

nc

nc

nc (IL-13, IL-1β, TGF-β1, TNF –α, IL-10)

nc PAS

[69]