Skip to main content
Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration

Fig. 6

PM2.5 exposure downregulates miR-574-5p expression. (a) Hierarchical clustering of miRNAs detected in the hippocampus of C57BL/6 J mice exposed to control or 5 mg/kg bw PM2.5 (n = 3 mice/group). Colors represent expression levels of each individual miRNA: black, mean vector for all miRNA expression levels; red, upregulation compared with mean vector; green, downregulation compared with mean vector. “C1”, “C2” and “C3” repsents three individual mice from control group, and “H1”, “H2” and “H3” repsents three individual mice from high dose group, respectively. (b) Significant changes in miR-574-5p levels detected via microarray and qPCR. The data are presented as the means ± SE (n = 6 to 8 mice/group). */# P < 0.05

Back to article page