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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease

Fig. 3

Representative images showing amyloid-β plaque staining in cortex (a, b, e and f) and hippocampus (c, d, g and h) of brains sections from 5XFAD mice. The accumulation of Aβ42 (reddish-brown colour) was localised by immunohistochemistry in sections of paraffin-embedded brain hemispheres. Hippocampus (50 x magnification) and cortex (100 x magnification) from the same animal are shown for each time point and exposure. i.e. 3 weeks to clean air (a and c), 3 weeks to DEE (b and d), 13 weeks to clean air (e and g) and 13 weeks to DEE (f and h), respectively

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