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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Prenatal tobacco smoke exposure predisposes offspring mice to exacerbated allergic airway inflammation associated with altered innate effector function

Fig. 2

Prenatal ETS exposure promotes a protracted predisposition to exacerbated allergic airway inflammation in the progeny. The effect of exposure to prenatal ETS or filtered air on the exacerbation of allergic airway inflammation was examined in a 18-week old, b 12-week old and c 7-week old C57BL/6 pups. The offspring mice (6 per group) were intranasally challenged with HDM allergen or PBS (control) and bronchoalveolar lavage fluid (BALF) was collected for analysis. Cell differential counts were determined and expressed as absolute cell numbers per mouse of lymphocytes (LYM), macrophages (MAC), eosinophils (EOS), and polymorphonuclear neutrophils (PMN). Eosinophil peroxidase (EPO) levels were assessed by colorimetric analysis. Results are mean ± SEM (n = 6) and representative of at least two independent experiments, ***p < 0.001, **p < 0.01 and *p < 0.05

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