Fig. 7
Specific CeO2 nanoparticle related histopathological findings. All examples illustrate findings after 3.0 mg/m3 CeO2 inhalation. a lung tissue with particle-laden macrophages (arrows), H&E, 33×, b inflammatory cell infiltrations with granulomatous inflammation (arrow) and alveolar/interstitial particle-laden macrophages, H&E, 37×, c bronchus-associated lymphoid tissue (BALT) with foci of particle-laden macrophages, H&E, 5×, d foci of particle-laden macrophages in lung-associated lymph nodes (LALN) (arrow), H&E, 40×; formation of syncytial giant cells (insert), H&E, 50×, e focal bronchiolo-alveolar hyperplasia (arrow), H&E, 53×, f very slight interstitial fibrosis (arrows) and particle-laden macrophages in alveolar tissue, Masson trichome, 40×