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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Interaction of rat alveolar macrophages with dental composite dust

Fig. 4

Membrane integrity of the cells was evaluated by the LDH (a) and the glucuronidase assay (b). Data are presented as mean and standard error of the mean. The concentration of filtered composite dust (X-axis) is expressed in μg/ml. The numbers above the bars indicate statistically significant differences compared to the control (1: p < 0.05; 2: p < 0.01 and 3: p < 0.001). The black dotted line in each diagram indicates the level of non-treated cell controls. Only the highest concentration of 180 μg/ml induced a significant increase in LDH and glucuronidase release. The relatively high values of 20–25% LDH (relative to the 0.1% Triton-X100 positive control, which releases all LDH from the cells) in the absence of particles are normal for NR8383 macrophages. As for the glucuronidase assay, only very mild effects of the treatment with composite dust can be observed when compared to the positive control (Quartz DQ12)

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