Items | Cu NPs (mg/kg/day) | |||
0 | 100 | 200 | 400 | |
No. of rats | 10 | 10 | 10 | 10 |
AST (IU/L) | 115.6 ± 19.32a | 125.2 ± 15.04 | 258.4 ± 21.52** | 626.6 ± 60.04** |
ALT (IU/L) | 23.7 ± 2.80 | 33.3 ± 12.95 | 88.4 ± 20.65** | 115.8 ± 19.12** |
ALP (IU/L) | 129.8 ± 12.45 | 132.0 ± 16.08 | 156.4 ± 22.06* | 175.7 ± 38.23** |
BUN (mg/dL) | 19.4 ± 2.02 | 20.2 ± 3.24 | 22.4 ± 1.39 | 40.6 ± 6.72** |
CRE (mg/dL) | 0.23 ± 0.052 | 0.24 ± 0.041 | 0.26 ± 0.058 | 0.38 ± 0.068** |
CPK (IU/L) | 519.0 ± 124.43 | 504.2 ± 99.57 | 480.5 ± 94.72 | 335.2 ± 94.70** |
TBIL (mg/dL) | 0.25 ± 0.071 | 0.24 ± 0.055 | 0.34 ± 0.036 | 1.07 ± 0.318** |
TCHO (mg/dL) | 77.6 ± 8.82 | 79.7 ± 8.94 | 78.7 ± 2.52 | 68.6 ± 14.36 |
TG (mg/dL) | 142.0 ± 25.52 | 133.4 ± 38.73 | 102.3 ± 29.10* | 87.3 ± 28.43** |
TP (g/dL) | 6.2 ± 0.21 | 6.1 ± 0.31 | 5.4 ± 0.25** | 5.4 ± 0.36** |
ALB (g/dL) | 4.2 ± 0.36 | 4.0 ± 0.12 | 4.0 ± 0.23 | 4.0 ± 0.17 |
LDH (IU/L) | 227.7 ± 79.76 | 268.4 ± 55.99 | 321.1 ± 57.63* | 462.3 ± 106.3** |
Na (mEq/L) | 141.8 ± 0.75 | 140.2 ± 1.35 | 140.3 ± 1.21 | 137.8 ± 2.95** |
Cl (mEq/L) | 97.6 ± 2.34 | 96.0 ± 1.17 | 95.8 ± 1.53* | 93.4 ± 1.14** |
K (mEq/L) | 4.5 ± 0.49 | 4.8 ± 0.28 | 5.1 ± 0.26 | 6.0 ± 1.04** |
Items | Cu MPs (mg/kg/day) | |||
 | 0 | 100 | 200 | 400 |
No. of rats | 10 | 10 | 10 | 10 |
AST (IU/L) | 113.7 ± 13.25 | 135.4 ± 29.86 | 138.6 ± 22.51 | 138.3 ± 21.89 |
ALT (IU/L) | 24.9 ± 7.91 | 27.3 ± 10.83 | 24.7 ± 4.28 | 24.8 ± 5.69 |
ALP (IU/L) | 124.7 ± 14.40 | 147.2 ± 20.99* | 120.4 ± 18.95 | 122.8 ± 11.17 |
BUN (mg/dL) | 17.3 ± 2.94 | 21.5 ± 4.85 | 21.5 ± 4.72 | 19.4 ± 3.67 |
CRE (mg/dL) | 0.23 ± 0.045 | 0.26 ± 0.062 | 0.27 ± 0.058 | 0.24 ± 0.056 |
CPK (IU/L) | 534.5 ± 106.82 | 522.7 ± 141.61 | 559.9 ± 80.12 | 516.9 ± 121.53 |
TBIL (mg/dL) | 0.23 ± 0.045 | 0.24 ± 0.062 | 0.26 ± 0.058 | 0.25 ± 0.056 |
TCHO (mg/dL) | 80.4 ± 6.41 | 77.7 ± 10.74 | 89.9 ± 15.03 | 77.7 ± 4.37 |
TG (mg/dL) | 132.3 ± 20.45 | 139.9 ± 20.17 | 149.4 ± 24.16 | 137.6 ± 20.76 |
TP (g/dL) | 6.4 ± 0.31 | 6.3 ± 0.47 | 6.1 ± 0.50 | 6.2 ± 0.16 |
ALB (g/dL) | 4.2 ± 0.17 | 4.2 ± 0.27 | 4.3 ± 0.22 | 4.2 ± 0.22 |
LDH (IU/L) | 256.8 ± 73.56 | 236.9 ± 61.90 | 298.9 ± 94.33 | 356.5 ± 98.59* |
Na (mEq/L) | 140.3 ± 1.16 | 141.1 ± 1.97 | 143.2 ± 1.14 | 141.6 ± 1.65 |
Cl (mEq/L) | 97.3 ± 1.42 | 98.9 ± 1.52 | 97.6 ± 1.65 | 99.0 ± 1.67 |
K (mEq/L) | 4.6 ± 0.32 | 5.1 ± 0.67 | 4.5 ± 0.36 | 4.6 ± 0.44 |