From: Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats
Male | Peto test | Female | Peto test | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Group (mg/m3) | 0 | 0.02 | 0.2 | 2 | 0 | 0.02 | 0.2 | 2 | ||
Number of animals examined | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | ||
Neoplastic lesions | ||||||||||
 Lung | ||||||||||
  Bronchiolo-alveolar carcinoma | 1 | 1 | 8 # | 10 ## | ↑↑ | 0 | 1 | 0 | 5 ## | ↑↑ |
  Adenosquamous carcinoma | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | ||
  Poorly differentiated adenocarcinoma | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | ||
  Squamous carcinoma | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | ||
  Total carcinoma | 1 | 1 | 8 # | 11 ## | ↑↑ | 0 | 1 | 0 | 8 ## | ↑↑ |
  Bronchiolo-alveolar adenoma | 1 | 1 | 7 # | 5 | 3 | 1 | 4 | 3 | ||
  Total adenoma and/or carcinoma | 2 | 2 | 13 ## | 16 ## | ↑↑ | 3 | 2 | 4 | 11 # | ↑↑ |
 Peritoneum | ||||||||||
  Malignant mesothelioma | 0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | ||
Non-neoplastic lesions | ||||||||||
 Lung | ||||||||||
  Bronchiolo-alveolar hyperplasia | 2 (1.5) | 6 (1.3) | 13 * (1.2) | 22 ** (1.0) | 3 (1.3) | 3 (1.0) | 8 (1.1) | 12 * (1.1) | ||
  Atypical hyperplasia | 0 | 0 | 1 (1.0) | 10 ** (1.3) | 0 | 0 | 0 | 14 ** (1.1) | ||
  Alveolar hyperplasia | 0 | 2 (1.0) | 13 ** (1.0) | 41 ** (1.0) | 1 (1.0) | 1 (1.0) | 6 (1.0) | 41 ** (1.1) | ||
  Bronchiolar hyperplasia | 0 | 0 | 4 (1.0) | 8 ** (1.0) | 0 (1.0) | 0 (1.0) | 4 (1.0) | 26 ** (1.0) | ||
  Accumulation: alveolar macrophage | 2 (1.0) | 7 (1.0) | 5 (1.0) | 48 ** (2.0) | 2 (1.0) | 6 (1.0) | 9 (1.0) | 48 ** (1.8) | ||
  Focal fibrosis: alveolar wall | 0 | 2 (1.0) | 43 ** (1.0) | 48 ** (1.8) | 0 | 3 (1.0) | 44 ** (1.0) | 49 ** (1.2) | ||
  Granulomatous change | 0 | 5 (1.0) | 42 ** (1.0) | 50 ** (1.9) | 0 | 3 (1.0) | 45 ** (1.0) | 50 ** (1.8) | ||
 Pleura | ||||||||||
  Simple mesothelial hyperplasia | 3 (1.0) | 3 (1.0) | 7 (1.0) | 12 * (1.0) | 3 (1.0) | 2 (1.0) | 6 (1.0) | 10 (1.0) | ||
  Focal fibrosis: parietal (diaphragm) | 0 | 0 | 2 (1.0) | 6 * (1.0) | 0 | 0 | 0 | 3 (1.0) | ||
  Focal fibrosis: ventral (lung) | 0 (1.0) | 2 (1.0) | 4 (1.0) | 19 ** (1.1) | 0 | 2 (1.0) | 2 (1.0) | 20 ** (1.0) | ||
Inflammation: mediastinum | 15 (1.0) | 18 (1.0) | 21 (1.0) | 26 * (1.0) | 17 (1.0) | 17 (1.0) | 16 (1.0) | 19 (1.0) | ||
  Inflammation: diaphragm | 0 | 0 | 1 (1.0) | 1 (1.0) | 0 | 1 (1.0) | 1 (1.0) | 1 (1.0) |