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Table 1 Description and values for non-inhalation specific pharmacokinetics parameters. Values in bold are fitted a

From: In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

Parameter (unit)

Description

Generic values b

Spleen (s)

Liver (l)

Lungs (lu)

Heart (h)

Kidneys (k)

GI tract (gi)

Brain (br)

Rest of the body (rest)

Blood (blood)

W t /WB (unitless) b

% of organ weight to body weight

-

0.0031

0.0396

0.0047

0.0034

0.0094

0.044

0.0053

0.84

0.0498

W t,b /W t (unitless) c

% of capillary blood in organ to organ weight

-

0.225

0.156

0.1

0.175

0.316

0.1

0.07

0.017

-

frQ t (unitless) d

Fraction of cardiac output to organ

-

0.0146

0.0465

1

0.051

0.141

0.213

0.02

0.514

1

N t (# per g) d

Phagocytizing cells number per organ weight

-

2.08 × 108

2.72 × 107

2.69 × 106, 3.90 × 10 6± 3.71 × 10 2 g

7.60 × 104

9.90 × 104

5.06 × 10 5± 2.22 × 10 3

3.06 × 105

8.11 × 106

1.85 × 103

M cap (μg per #) f

Maximum uptake capacity in individual phagocytizing cells

5.52 × 10 −7± 6.98 × 10 −11

-

-

-

-

-

-

-

-

-

χ α (unitless) f

Permeability coefficient between blood and tissue

7.76 × 10 −1± 2.14 × 10 −4

Generic

Generic

Generic

Generic

Generic

Generic

6.75 × 10 −7± 8.84 × 10 −11

1.71 × 10 −2± 6.54 × 10 −7

-

P (unitless) f

Partition coefficient between tissue and blood

2.09 × 10 −1± 9.83 × 10 −7

Generic

Generic

Generic

Generic

Generic

Generic

Generic

Generic

1

k ab0 (per h) f

Maximum uptake rate by phagocytizing cells

1.45 × 10 0± 4.62 × 10 −5

5.18 × 10 −1± 5.87 × 10 −5

Generic

Generic

Generic

Generic

Generic

Generic

Generic

Generic

k de (per h) f

Desorption rate by phagocytizing cells

5.30 × 10 −19± 1.24 × 10 −17

Generic

Generic

Generic

Generic

Generic

Generic

Generic

Generic

Generic

CLE e (per h)

Clearance rate to excreta

-

-

1.52 × 10 −3± 6.97 × 10 −6

-

-

3.26 × 10 0± 2.70 × 10 −3

1.41 × 10 −1± 8.42 × 10 −7

-

-

-

fr β (unitless) e, f

Fraction of capillary blood of organs left when analyzed

0.144

Generic

Generic

Generic

Generic

Generic

Generic

0.371

Generic

-

  1. a “-” stands for not applicable
  2. b Values were obtained by from Wenger et al. [45] except for the GI tract, which was obtained from Bernareggi and Rowland [42]
  3. c Values were obtained from literature estimates of the percentage (w/w) of capillary blood in the organs [41] except for lungs and GI tract, which were estimated by the authors
  4. d Values obtained from literature [15, 42, 43]
  5. e Values obtained from Carlander et al. [35]
  6. f M cap , χα, P, k ab0 , k de, fr β have generic values for most compartments. “generic” indicates the corresponding generic value for each parameter
  7. g 2.69 × 106 is for the lungs interstitium, 3.90 × 106 ± 3.71 × 102 is for the pulmonary region of the lungs