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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Long-term exposure to commercially available sunscreens containing nanoparticles of TiO2 and ZnO revealed no biological impact in a hairless mouse model

Fig. 2

Images of representative histological skin sections from mice from Series 1 and 2 receiving: a no treatment; b weekly exposure to UVR with no sunscreen; c weekly exposure to UVR with pre-applications of sunscreen containing nanoparticles of ZnO as the only UV active ingredient; d weekly exposure to UVR with pre-application of sunscreen containing nanoparticles of TiO2 and organic UV active ingredients; e weekly exposure to UVR with pre-application of sunscreen containing only organic UV active ingredients. Images on the left were taken from mice in Series 1, and on the right in Series 2. The only treatment-specific effects were in the mice receiving UVR treatments with no sunscreen (Control + UVR), here represented by a squamous cell papilloma (SCP) in Series 1 (encompassed by a black bracket), and in Series 2 (i) a cutaneous fibrosarcoma (CFS) (black arrow indicates mitotic figure in fibrosarcoma) and (ii) squamous cell carcinoma (SCC) (black arrow indicates “keratin pearl” in SCC). The skin from all other treatment groups showed unremarkable epidermis and dermis

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Particle and Fibre Toxicology

ISSN: 1743-8977

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