Fig. 4From: Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matterHeatmap with hierarchical cluster analysis of cytotoxic potency of particles in J774A.1 (a) and A549 (b) cells based on cytokine release after 24 h exposure to particles. Inflammatory potency estimate, βI-V for J774A.1 (c) and A549 (d) cells representing the average cytokine potency adjusted for cell viability. The βI-V LO represents the lower estimate (IL-10 and IL-6 potency subtracted from average potency), while βI-V HI is the higher estimate (IL-10 potency subtracted, IL-6 added to average potency). Within the heatmaps, red color represents increased inflammatory potency of particles (increased cytokine/chemokine levels; positive β), whereas green color represents decreased inflammatory potency (negative β)Back to article page