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Table 6 Type and incidence of histological lesions in the liver on days 1, 3 and 28 following exposure of mice to CNT, EPOXY-REF, EPOXY-CNT, EPOCYL or CB

From: Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

Lesion

Control

CNT (μg/animal)

EPOXY-REF (μg/animal)

EPOXY-CNT (μg/animal)

EPOCYL (μg/animal)

CB (μg/animal)

0

18

54

162

54

162

486

54

162

486

54

162

486

162

Foci (small) of inflammatory cells

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

1/6

0/6

2/5

0/6

0/6

0/6

0/6

1/6

1/6

0/6

2/6

1/6

0/6

 Day 28

0/24

2/6

1/6

1/6

0/6

0/6

0/6

1/6

2/6

2/6

1/6

2/6

2/6

0/6

Granuloma

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

0/6

1/6

1/5

0/6

0/6

0/6

0/6

0/6

1/6

0/6

2/6

2/6

0/6

 Day 28

0/24

2/6

2/6

1/6

0/6

0/6

0/6

0/6

1/6

1/6

1/6

1/6

2/6

0/6

Polymorphonuclear cell foci

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

0/6

1/6

1/5

0/6

0/6

0/6

0/6

0/6

1/6

0/6

1/6

1/6

1/6

 Day 28

0/24

2/6

1/6

3/6

0/6

0/6

0/6

1/6

1/6

0/6

1/6

1/6

2/6

2/6

Macrophages

 Day 1

0/12

2/6

1/5

1/6

0/6

0/6

0/6

1/6

0/6

0/6

0/6

1/6

0/6

0/6

 Day 3

0/22

1/6

2/6

1/5

0/6

0/6

0/6

1/6

2/6

2/6

1/6

2/6

2/6

0/6

 Day 28

0/24

1/6

2/6

2/6

0/6

0/6

0/6

0/6

2/6

2/6

1/6

1/6

1/6

0/6

Hyperplasia of connective tissue perivascular

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

0/6

0/6

1/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 28

0/24

0/6

0/6

1/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

1/6

0/6

Hyperplasia of connective tissue near bile ductless or venules

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

0/6

0/6

1/5

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

1/6

 Day 28

0/24

0/6

1/6

1/6

0/6

0/6

0/6

0/6

0/6

1/6

0/6

1/6

2/6

2/6

Microfoci of necrosis

 Day 1

0/12

1/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

0/6

0/6

1/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

2/6

1/6

 Day 28

0/24

1/6

2/6

2/6

0/6

0/6

0/6

0/6

0/6

1/6

0/6

1/6

1/6

1/6

Eosinophilic necrosis of single hepatocytes

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

0/6

1/6

1/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 28

0/24

2/6

1/6

2/6

0/6

0/6

0/6

1/6

0/6

1/6

0/6

1/6

1/6

1/6

Hepatocytes with pyknotic nuclei

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

0/6

1/6

1/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

1/6

 Day 28

0/24

1/6

2/6

2/6

0/6

0/6

0/6

1/6

0/6

1/6

1/6

1/6

2/6

1/6

Parenchymatous degeneration

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

0/6

1/6

1/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

1/6

 Day 28

0/24

1/6

2/6

2/6

0/6

1/6

0/6

0/6

1/6

1/6

0/6

2/6

2/6

2/6

Vacuolar degeneration

 Day 1

0/12

0/6

1/5

2/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

2/6

2/6

0/6

 Day 3

0/22

2/6

2/6

3/5

0/6

0/6

1/6

0/6

1/6

2/6

1/6

2/6

3/6

2/6

 Day 28

0/24

1/6

2/6

2/6

0/6

0/6

1/6

0/6

3/6

3/6

0/6

3/6

2/6

2/6

Binucleate hepatocytes

 Day 1

1/12

2/6

1/5

1/6

0/6

0/6

0/6

1/6

1/6

0/6

1/6

0/6

1/6

0/6

 Day 3

1/22

1/6

2/6

2/5

1/6

2/6

1/6

0/6

1/6

2/6

1/6

2/6

1/6

2/6

 Day 28

2/24

2/6

2/6

3/6

1/6

1/6

1/6

2/6

1/6

1/6

2/6

1/6

2/6

2/6

Oedematous endothelial cells of portal venules or close to blood vessels

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

0/6

0/6

1/5

0/6

0/6

0/6

0/6

0/6

1/6

0/6

0/6

0/6

1/6

 Day 28

0/24

0/6

2/6

2/6

0/6

0/6

0/6

0/6

1/6

1/6

0/6

1/6

2/6

2/6

Increased number (hyperplasia) of Kupffer cells

 Day 1

0/12

0/6

0/5

1/6

1/6

0/6

1/6

0/6

0/6

0/6

0/6

0/6

1/6

0/6

 Day 3

0/22

1/6

1/6

2/5

0/6

0/6

0/6

0/6

2/6

2/6

1/6

1/6

1/6

1/6

 Day 28

0/24

1/6

2/6

1/6

0/6

0/6

1/6

1/6

1/6

1/6

1/6

1/6

2/6

1/6

Hypertrophy of Kupffer cells

 Day 1

0/12

0/6

2/5

2/6

0/6

0/6

0/6

0/6

0/6

1/6

2/6

2/6

2/6

0/6

 Day 3

0/22

0/6

3/6

2/5

0/6

1/6

1/6

1/6

2/6

1/6

1/6

2/6

1/6

0/6

 Day 28

0/24

1/6

2/6

3/6

0/6

0/6

1/6

0/6

1/6

1/6

0/6

2/6

2/6

1/6

Hyperplasia of bile ducts epithelium

 Day 1

0/12

0/6

0/5

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

0/6

 Day 3

0/22

1/6

2/6

1/5

0/6

0/6

0/6

0/6

0/6

0/6

1/6

0/6

1/6

0/6

 Day 28

0/24

1/6

1/6

1/6

0/6

0/6

1/6

1/6

1/6

1/6

2/6

2/6

1/6

2/6