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Table 2 BALF protein analysis at 1 day, 7 days and 1 month

From: Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family

 

1 Day

7 Day

1 Month

Protein

Gr20 - High

Gr5 - High

Gr1 - High

CB - High

Gr20 - High

Gr5 - High

Gr1 - High

CB - High

Gr20 - High

Gr5 - High

Gr1 - High

CB - High

Apo A-1

3.44 b,c

3.02 b,c

1.54

2.57 b

0.98

0.76

0.73

0.48

1.26

1.34

1.24

0.94

CRP Mouse

1.94 c

1.53 c

1.18

1.29

1.07

1.07

0.80

1.00

1.29

1.21

1.29

1.07

CD40

BLD

BLD

BLD

1.36 e

BLD

1.63

BLD

1.69

BLD

BLD

BLD

BLD

CD40L

26.74 c

35.13 c

9.3 b

33.74 c

2.41

2.76

0.97

3.04

1.00

1.13

0.62

0.78

Eotaxin

3.2 c

6.46 c

1.36 b

2.04 c

1.46

1.56

1.22

1.22

1.07

1.08

1.10

0.94

EGF Mouse

2.63 b,c

3.12 c

2.34 b

3.12 c

2.46 a

2.28 a

2.06 a

2.02 a

0.84

0.94

0.68

0.68

Factor VII

1.83 b

2.53 c

1.66 b

2.23 c

1.73

1.41

1.47

1.39

1.08

1.11

1.07

0.98

Fibrinogen

2.77 c

2.35 c

1.26

2.07 c

1.29

0.94

0.79

1.12

1.35 a

1.28

1.23

1.11

GCP-2 Mouse

1.83 b

2.70 c

2.94 c

3.17 c

2.12 c

1.71 c

2.27 c

1.68

1.04

0.89

0.70

0.97

GM-CSF

2.39 b

5.75 c

4.49 c

24.48 e

2.02

1.36

1.71

1.18

1.15

1.06

0.87

0.92

KC/GRO

4.17 b

12.5 c

7.08 c

23.33 e

BLD

BLD

BLD

BLD

BLD

BLD

BLD

BLD

IgA

0.93

1.64

1.00

1.30

0.86

0.84

0.80

0.65

1.18

1.00

0.99

1.03

IP-10

10.76 b

14.28 b

1.98

7.59 b

1.48

1.58

1.48

2.47

0.84

1.02

0.93

1.02

IL-1α

1.86 b

2.66 c

1.78 b

3.32 c

2.45

3.46

2.62

2.57

1.26

1.55

0.42

1.31

IL-1β

1.26

2.00

1.01

2.08 c

0.99

1.03

0.82

0.87

0.72

1.22

1.32

1.12

IL-5

6.22 d

8.49 d

1.26

2.26 c

BLD

BLD

BLD

BLD

BLD

BLD

BLD

BLD

IL-6

16.34 c

39.02 e

4.65 b

13.99 c

BLD

BLD

BLD

BLD

BLD

BLD

BLD

BLD

IL-18

1.60 b

2.26 c

1.50 b

2.74 c

0.99

1.35

0.96

1.10

0.81

1.17

0.92

1.06

LIF

3.91 c

6.57 d

1.99 b

3.01 c

2.2 5 a

1.81

1.89

1.62

1.00

0.98

0.81

0.87

Lymphotactin

1.61

2.39 c

1.14

1.91

1.18

1.10

1.17

1.42

0.62

0.81

1.00

1.01

 M-CSF-1

1.62 b

2.31 c

1.62 b

3.91 e

1.32

1.22

1.03

1.19

1.18 c

1.27 c

0.97

0.92

 MDC

6.04 c

8.58 e

1.78

4.09 c

2.34 a

1.84 a

1.51 a

1.78 a

1.63 c

1.76 c

1.10

1.36

 MIP-1α

2.84 c

4.12 d

1.70 b

3.56 d

2.50

2.32

2.40

1.71

1.82

3.33 b

1.81

1.50

 MIP-1β

14.51 c

14.99 c

3.09 b

12.94 c

1.40

1.79

1.46

2.13

0.82

1.25

0.75

0.74

 MIP-1γ

6.33 c

9.03 c

3.94 b

10.35 c

2.95 a

3.78 a

1.38

2.11

2.75 c

3.69 c

1.30

1.69

 MIP-2

4.54 c

5.54 c

2.94 b

5.70 c

2.26 a

1.93

1.89

1.76

0.76

0.96

0.60

0.85

 MIP-3

2.34 c

3.56 e

1.78 b

2.50 c

2.13 a

2.08 a

2.15 a

1.95 a

1.17

1.09

0.88

1.01

 MMP-9

71.42 c

52.44 c

11.19 b

46.72 c

4.08

4.51

2.46

4.90

2.07 c

1.87 c

0.63

0.95

 MCP-1

17.86 c

25.76 c

0.98

15.54 c

BLD

BLD

BLD

7.06

BLD

BLD

BLD

BLD

 MCP-3

38.32 c

42.07 c

3.01 b

21.82 c

1.18

3.57 a

1.65 a

5.56 a

1.13

2.04 e

0.97

1.05

 MCP-5

9.27 c

10.11 c

BLD

5.38 c

BLD

BLD

0.73

1.03

BLD

BLD

BLD

BLD

 MPO

51.27 c

66.02 d

18.32 c

62.77 d

21.78 a

20.26 c

7.23 a

25.24 c

4.68 c

3.58 c

0.59

1.01

 PAI-1

1.84 c

2.63 e

1.50 b

1.64 c

1.17

1.11

0.98

1.21

1.12

1.37

1.15

1.14

 SAP

2.63 b,c

2.03 b

1.09

1.50

1.38

1.00

0.68

0.71

1.00

0.97

1.13

0.63

 SCF

2.36 b

3.37 c

1.39

2.66 c

0.88

1.43

1.51

2.09

1.26

0.88

0.82

0.83

Thrombopoetin

2.53 b

4.17 c

2.20 b

4.42 c

1.47

1.03

BLD

BLD

BLD

1.58

BLD

BLD

 TIMP-1

17.32 d

18.88 d

2.95 b

7.49 c

1.59

1.82 a

1.12

1.18

1.37

1.53 c

1.30

1.97

 TNF-α

BLD

3.90 e

BLD

BLD

BLD

BLD

BLD

BLD

BLD

BLD

BLD

BLD

 VCAM-1

1.88 c

2.08 c

1.30

1.86 c

1.13

1.21

0.84

1.07

1.16

1.20

1.08

0.98

 VEGF-A

2.16 c

2.45 c

1.44 b

2.49 c

1.14

1.08

1.04

1.04

0.96

0.98

0.93

0.85

 vWF

1.76 b

2.10 b

1.73 b

2.33 c

1.63

1.63

1.52

1.29

1.22

1.11

1.00

1.05

  1. Data in the table represent fold-increase for proteins that were significantly different for one or more groups at one or more time points post-exposure based on RodentMap® v2.0. The low dose groups were tested only at 1 day post-exposure. BLD – below the limit of detection. Groups with like symbols denote statistically similar group; astatistically different from DM only; bstatistically different from DM and all low dose groups; cstatistically different from DM and at least one high dose group; dstatistically different from statistically different from DM, low dose groups, and at least one high dose group; estatistically different from all groups; p < 0.05. Bold text without symbols denotes significance at p < 0.07