Fig. 1From: Nickel oxide nanoparticles can recruit eosinophils in the lungs of rats by the direct release of intracellular eotaxinCytological analysis of BALF after intratracheal instillation of NiO NPs, NiCl2, and OVA. NiO NPs were instilled at 200 cm2/rat and cytological evaluation was performed at 1, 2, 3, and 4 days after instillation. NiCl2 was instilled at 378.0 μg/rat, which is equivalent to the nickel dose (171.1 μg Ni/rat) of NiO NPs at 200 cm2/rat, and cytological evaluation was performed at 1 day after instillation. a, Number of total cells. b Number of macrophages. c Number of neutrophils. d Number of eosinophils. Abbreviations: VEH, vehicle control for NiO NPs and NiCl2; OVA, ovalbumin-induced allergic airway inflammation; VEHOVA, vehicle control for OVA group. Mean ± SEM (n = 10 for NiO NPs and n = 4 for NiCl2 and OVA group). One-way ANOVA test was applied for comparison between NiO NPs and VEH with statistical significance indicated by * p < 0.05, ** p < 0.01, and *** p < 0.001. Student’s t-test was applied for comparison of NiCl2 against VEH and OVA group against VEHOVA with statistical significance indicated by ## p < 0.01 and ### p < 0.001Back to article page