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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Persistent effects of Libby amphibole and amosite asbestos following subchronic inhalation in rats

Fig. 7

Stop-exposure inhalation study: persistent effects on histopathology 18 months after exposure to AM or LA for 13 weeks. All images shown are from 10 mg/m3 LA target mass concentration except panel E (3.3 mg/m3 LA). Images represent a alveolar inflammation (macrophages) with intracytoplasmic fibers (arrowheads), b interstitial fibrosis (indicated by blue-stained collagen), c subpleural fibrosis (lower image) compared to normal pleura (upper image), d alveolar epithelial hyperplasia (indicated by cuboidal type II pneumocytes lining alveolar walls), e bronchiolar/alveolar (B/A) adenoma, and f B/A carcinoma. Slides were stained with either hematoxylin and eosin (a, d–f) or Masson’s trichrome (b, c). Images were taken at 60x (a), 40x (b, c), or 20x (d–f) objective magnification

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