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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Persistent effects of Libby amphibole and amosite asbestos following subchronic inhalation in rats

Fig. 6

Long-term stop-exposure inhalation study: lung pro-inflammatory cytokines and markers of Akt and ERK pathway activation from right cranial lung lobe tissue. Rats were exposed for 13 weeks to AM or LA and evaluated at 1 day, 1, and 3 months after the end of the exposure. Values in legend represent target mass concentrations (mg/m3). Results show mean values ± SE (n = 6–7 rats per group). a Cytokine levels expressed relative to total protein in sample. b Phosphorylated components of Akt pathway (pAkt, pS6RP) and MAPK/ERK cascade (pMEK1/2, pSTAT3) expressed relative to levels in air control group. P < 0.05 † vs. all other groups; * vs. air control; # vs. LA 1.0; ‡ vs. AM 3.3; § vs. LA 3.3

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