Fig. 6
From: Silica coating influences the corona and biokinetics of cerium oxide nanoparticles
Quantitative assessment of uptake of CeO2 by alveolar macrophages at 24 h post-instillation. BAL cells were analyzed using hyperspectral imaging. a The image shows uncoated and silica-coated CeO2 mapped as bright pixels (pointed arrows) inside the cells. BAL cells isolated at 24 h and 5 days after IT-instillation were scored. b Numbers of macrophages with or without internalized CeO2 at 1 and 5 days post-instillation. Significantly more cells with ingested silica-coated CeO2 were seen at 5 days. Data are mean ± SEM, n = 3 rats/group, n = 3000 cells scored/group. * P < 0.05, Student t test