Fig. 3
From: Silica coating influences the corona and biokinetics of cerium oxide nanoparticles
Biokinetics of IT-instilled 141CeO2 nanoparticles. a Lung clearance of both CeO2 NPs was slow. Although similar during the first two days post-IT instillation, it was different between from day 2 to day 7. Approximately 22 % of silica-coated CeO2 and only ~8 % of uncoated CeO2 total dose cleared the lungs during this period. By 28 days post-instillation, 81 % of uncoated and 66 % of silica-coated CeO2 remained in the lungs. b Translocated 141Ce from the lungs gradually accumulated in extrapulmonary organs. By 28 days, only 0.9 % of instilled 141Ce dose from uncoated and 0.7 % from silica-coated CeO2 were retained in all extrapulmonary organs examined. Data are mean ± SEM, n = 5/group