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Table 3 Histopathology scores of exposed and control pregnant and non-pregnant groups immediately after delivery on GD 19 (PND 0) and 50 days later (PND 50)

From: Effects of prenatal inhalation exposure to copper nanoparticles on murine dams and offspring

Experimental Group

Number of mice per group

Histopathology Scorea

Alveolar macrophages

Alveolar debris

Perivascular cuffingb

Exposed

Pregnant, PND 0

n = 4

1

2

0.75

Non-Pregnant, PND 0

n = 5

1

1

1.8

Pregnant, PND 50

n = 5

1

0

0.2

Non-Pregnant, PND 50

n = 5

0.6

0

0.2

Shams

Pregnant, PND 0

n = 4c

0

0

0

Non-Pregnant, PND 0

n = 4c

0

0

0

  1. PND postnatal day
  2. aScoring system: 0 = none, 1 = few/rare, 2 = multifocal/moderate, 3 = many/coalescing and/or diffuse
  3. bLymphocytes and plasma cells surrounding blood vessels
  4. cOnly 4 mice out of 5 were evaluated for pathology changes in control groups