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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

Fig. 3

Microscopic appearance of lungs around terminal bronchiole and tracheochonchial lymph nodes 24 h or 90 days after a 90-day exposure to 5.0 mg/m3 of Graphistrength© C100. a End of exposure. Presence of black particles within the alveolar macrophages (blue arrow) and tissue macrophages (red arrow). Note the interstitial inflammation around the alveolar duct with macrophages arranged as a small nodule-like structure (black arrow), forming concentric layers around black particles. b End of exposure. Presence of black particles within alveolar macrophages (blue arrow) or free within the alveolar lumen, admixed with the eosinophilic material (black arrow). c End of exposure. Presence of black particles within the alveolar macrophages (blue arrow) and tissue macrophages (red arrow) around a blood vessel. Note the intact pleura (black arrow). d End of recovery. Presence of interstitial collagen fibers protruding within the alveolar lumen (blue arrow) (e) End of exposure. Presence of black particles (blue arrow) in tracheobronchial lymph node associated with increased lymphocytes in the cortex/paracortex. f End of recovery. Tracheobronchial lymph node with large deposit of black particles (blue arrow). Original lens magnification: (a), (b), (c) and (d): 40-fold; (e): 6.3-fold; (f): 25-fold

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Particle and Fibre Toxicology

ISSN: 1743-8977

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