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Fig. 9 | Particle and Fibre Toxicology

Fig. 9

From: Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments

Fig. 9

Comparison of the PBPK model to biokinetic data from female Wistar-Kyoto rats [20] 24 h after intratracheal instillation of various sizes of AuNP. (only organs where the gold levels in all rats were above the LOD are depicted; data are expressed as mean ± SD, n = 4 (rats) and n = 1000 iterations (PBPK model), *unit for urine: % dose)

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