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Table 1 Total gold content of tissues 6, 12 and 24 hours following oral exposure to gold nanoparticles

From: Oral absorption of PEG-coated versus uncoated gold nanospheres: does agglomeration matter?

 

6 Hour

12 Hour

24 Hour

Total Au content (ng)

Total Au content (ng)

Total Au content (ng)

(SD)

(SD)

(SD)

PEG-coated

Uncoated

PEG-coated

Uncoated

PEG-coated

Uncoated

Blood

22.2

18.7

38.1

13.2

227.1*

93.8

(5.0)

(6.7)

(26.2)

(2.2)

(120.6)

(32.5)

Liver

378.1**

103.0

162.3

89.1

21.2

19.1

(166.9)

(12.1)

(81.8)

(20.6)

(3.7)

(3.7)

Spleen

3.8

9.4

18.2

2.2

15.3**

11.1

(1.0)

(14.6)

(18.9)

(0.8)

(2.3)

(1.4)

Kidney

13.1

9.3

19.3

9.5

13.6***

9.3

(2.5)

(1.3)

(10.8)

(1.1)

(1.9)

(1.2)

Heart

219.1**

10.4

40.6**

9.0

21.6***

6.1

(155.5)

(3.3)

(15.0)

(1.7)

(6.9)

(0.7)

Lung

5.5

66.1

12.4

3.7

4.4***

2.9

(0.4)

(124.9)

(10.0)

(1.0)

(0.8)

(0.1)

Testes

2.5

3.1

4.9

2.4

2.3

2.4

(0.2)

(1.1)

(4.8)

(0.3)

(0.5)

(0.4)

Brain

1.8

0.9

3.8

1.0

1.5**

0.6

(0.3)

(0.1)

(3.6)

(0.3)

(0.5)

(0.1)

  1. Asterisks indicate statistically significant differences in total gold content for tissues from mice dosed with PEG-coated versus uncoated gold particles for each time point. * indicates a p-value ≤ 0.05, ** indicates a p-value ≤ 0.01 and *** indicates a p-value ≤ 0.005. For all groups, averages are based on n = 5, and standard deviations are shown in parentheses below each average.