Figure 3
From: Why does the hemolytic activity of silica predict its pro-inflammatory activity?
IL-1β release from primary murine macrophages induced by different silica particles. LPS-primed primary murine macrophages were incubated with 20 cm2/ml of silica for 6 h and then evaluated for IL-1β production (pg/ml) in culture supernatants by ELISA. The silica samples were a commercial quartz (Qz-1), the same heated at 800°C (Qz-2), a vitreous silica (VS), a pure quartz (Qz-3) and the pure quartz etched with HF (Qz-4). ATP (5 mM) was used as positive control. Values are mean ± SD including data from three independent experiments. ***p < 0.001 vs control not exposed to silica particles.