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Figure 5 | Particle and Fibre Toxicology

Figure 5

From: Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

Figure 5

Dependence of the exposure regimen on the predicted volumetric cumulative PSP volume at the kinetic overload threshold of 4.2 μL/kg rat (dashed horizontal line; for details see [[4]] ). For each of the shown C × Σt –relationships, this threshold is anticipated to be the NOAEL in case MoAI-related findings do not increase at a higher ‘C’ and shorter ‘t’ [36]. The ratio of this PSP volume to the respective dose rate to attain overload under any given condition is used to calculate the accumulation factor fv (insert) to estimate the generic retention-related (MoAII) NOAEL (see Figure 7).

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Particle and Fibre Toxicology

ISSN: 1743-8977

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