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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

Figure 4

Modeling of two C × Σt-adjusted subchronic barium sulfate inhalation studies with different particle size and surface areas from Cullen et al. [[9],[32]]. Symbols were reproduced from figures given by these authors. The elimination half-time of BaSO4 in the lung of t1/2 ≤ 60 days as well as the fact that the equal C × Σt of the longer exposure period produced half the lung burden of the shorter exposure period suggest enhanced dissolution of particles. Fitted curves represent a 1st-order kinetics (for details see [4]). Opposite to the recommendation given in Figure 1, data had to be fit to the accumulation rather than the data lean elimination phase. This circumstance decreased the precision of analysis; however, elucidate further the intricate relationship of dissolution at possibly saturated conditions and MoAII-related clearance.

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