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Figure 2 | Particle and Fibre Toxicology

Figure 2

From: Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

Figure 2

Schematic representation outlining the interrelationship of inhaled dose and kinetics, the ensuing effect, and the sub-compartments of the lung were these dose-effect relationships are believed to occur for poorly soluble particles (Zn-chelate) at 1, 5, and 25 mg/m3and less soluble particles (ZnO) at 7 mg/m3(the last two concentrations were adjusted to attain equivalent molar concentrations of Zn). Rats were exposed for 6 hours/day on seven consecutive days. Zn was determined in lung tissue and bronchoalveolar (BAL) cells on postexposure days 1, 3, and 15. The findings presented demonstrate that solubility may affect the compartment were dissolution and toxicity occurs. The highest toxicity occurred in ZnO-exposed rats at lower concentration of total dust (for more details see ref. [32]), which delineates the importance of dissolution rate and flux (for details see [31],[32]).

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